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The radio therapy process planning
Slavíček, Tomáš ; Kolářová, Jana (referee) ; Hrozek, Jan (advisor)
This thesis aims to bring reader to the problems of radiotherapy, to give him an overview of basic principles and methods used to treat patients with cancer by ionizing radiation. The first part is devoted to the physical description of radiation and means of quantification. Interactions of radiation with matter are discussed next following with characterization of radiation effects on living cells and tissues. In the next part there is a description of the devices used in the treatment by ionizing radiation and an explanation of the various acts of patient's preparation from the target localization to irradiation. The final chapter describes created program with a graphical environment, which includes the key elements of commercial planning systems for the creation of the irradiation plan. This program uses real CT images and provides the user a basic idea of creating radiotherapeutic plan. The user has several functions for creating and optimizing the plan. The output of the program is a graphical representation of the spatial distribution of dose in the patient's body.
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Simulation of dose distribution irradiation
Večeřa, Petr ; Hlaváč, Martin (referee) ; Kolářová, Jana (advisor)
This project deals with the issue of simulation of dose irradiation. This principle is used in a radiotherapeutic device known as a Leksell Gamma Knife for the treatment of intracranial tumours. With regard to the theoretical observations obtained by studying this device, the project suggests the use of analytical geometry for the creation of a mathematical model for calculation of the intensity in the rayed area. A demonstration program Leksell_xvecer08 has been created for this model in a MatLab software background, which enables the user to change various input arguments and simulate a picture of the dosage spread in the target scanned areas.
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Radiotherapy
Šipka, Petr ; Janoušek, Oto (referee) ; Kolářová, Jana (advisor)
The goal of this thesis is to familiarize readers with the basics of the problem of electromagnetic and ionizing radiation, with its effects on a biological tissues and with types of ionizing radiations used in a therapy. It deals with a medical procedures in therapy planning and with procedures during therapy itself. Part of this Bachelor’s thesis is an application Radiation Calculator processed in MatLab software. Application is modeling the resulting radiation field while setting various parameters.
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Spectral computed tomography: comparison of real and virtual nativ images
Širůčková, Kateřina ; Bartušek, Karel (referee) ; Marcoň, Petr (advisor)
Advanced X-ray medical diagnostic methods massively increase the radiation exposure of patients. Therefore, it is necessary to focus on the reduction of radiation and its stochastic and deterministic effects. This project compares real native images TNC with virtual native images VNC. Virtual native images are acquired by spectral computed tomography method and it is suggested that VNC could potentially substitute real native images, thereby, the total radiation dose from multiphase spectral CT would decrease. A comparison was performed by defining certain parameters that represented the differentiation of the measured and calculated values in the images. The parameters were SNR, CNR, absolute difference, relative error and they were analysed by statistical tests using p-value and correlation analysis. Another output is a database of patients with compared parameters from real and virtual native images.
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Radiotherapy planning
Kumpová, Ivana ; Sekora, Jiří (referee) ; Kolářová, Jana (advisor)
The task of this thesis is to familiarize readers with the basics of the problem of ionizing radiation from its types and resources, through mechanisms of action and its effects on the human organism, to the possibility of calculating various characteristics. Close attention is paid to the use of ionizing radiation in medical approaches. There is in detail described process of radiotherapy planning and a basic properties of planning systems. Part of the thesis is also program RT-Plan processed in Matlab. The program simulates the planning system for external ionizing radiation therapy used in treatment. There is supplemented a detailed help and series of tests for the plan. It is suitable for possible use in teaching.
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Treatibility of surface water
Fuks, Josef ; Palčík,, Jiří (referee) ; Kučera, Tomáš (advisor)
The aim of the master´s thesis is the topic of the treatability of surface water with the focus on the process of suspension formation. For this work I took water samples from five different places around the Brno Dam which has contended with water quality deterioration for a long period. With these water samples, the series of jar coagulation tests were done with the application of three different commonly used coagulants. In the theoretical part of the master´s thesis I deal with the composition and attributes of surface water and the technology of its treatment. Each process of treatment is briefly described here with the emphasis on the process of suspension formation. The experimental part of the master´s thesis summarizes and presents the results gained through the coagulation tests in the laboratory. I evaluate the influence of different parameters on final effectiveness of water treatment and I try to find an optimal amount of coagulant, pH and speed of fast or slow mixing. Finally I compare the suitability of each coagulant and the influence of the sampling site on the effectiveness of water treatment.
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Medical Software for Accounting
Pohl, Ondřej ; Veselý, Vladimír (referee) ; Grégr, Matěj (advisor)
The aim of this thesis is an extension of medical software OpenDositech. Implementation of interface for communication with portals of insurance companies is extension into OpenDositech program. In the first part available medical softwares are described together with API for sending. The thesis next deals with the Portal of insurance companies. At the end the thesis describes implementation of the API into OpenDositech program.
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Effect of caffeine on maximal strength of the complex exercises
Šťastný, Daniel ; Třebický, Vít (advisor) ; Petr, Miroslav (referee)
Title: Effect of caffeine on maximal strength of the complex exercises Objectives: The main aim of this theses is to investigate caffeine's effect on the maximum strength of the deadlift exercise. The sub-objectives of the thesis are to test whether the magnitude of the effect of caffeine differs between the upper half of the body compared to the lower half, and also whether caffeine has an effect on the production of maximal strength after insufficient rest. Methods: The randomized double-blind study consisted of 1 baseline and 2 experimental sessions . At the start of the experimental sessions, participants were given either caffeine (3 mg/kg) or placebo 60 min before testing. In a randomized order, maximal isometric strength with sufficient rest between reps was measured for the deadlift (IMT) and benchpress (IBP) exercises. Subsequently, maximal isometric strength was measured for the isometric mid-thigh (IMTP) exercise after insufficient rest. A total of 36 healthy resistance-trained men habituated to caffeine consumption participated in this study Results: RM ANOVA showed that caffeine increased performance at IMT, compared to placebo (d = 0.229 [0.61, 0.397]), but not compared to baseline. For the IBP exercise, caffeine has no effect compared to placebo, but baseline session was...
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Dose-response curves
Hezoučký, Martin ; Hlávka, Zdeněk (advisor) ; Maciak, Matúš (referee)
Title: Dose-response curves Author: Martin Hezoučký Department: Department of Probability and Mathematical Statistics Supervisor: doc. RNDr. Zdeněk Hlávka, Ph.D., Department of Probability and Mathematical Statistics Abstract: In this thesis, we deal with the process of research and development of new medical substances with a focus on statistical methods used to determine appropriate doses. For this purpose, we examine the dose-response relationship. First, we describe a typical procedure for the development of a new drug. Second, we focus in detail on the MCP-Mod method. Third, we propose a new method based on the theory of gradual change models. This approach tests whether the administration of the drug has a significant effect. If so, the dose with desired effect is estimated using an appropriate model. Specifically, we provide an esti- mate using linear, quadratic and Emax gradual change models. We also describe a construction of a confidence interval for the point of change and also for the dose with the desired effect. The advantage of the proposed method over the MCP-Mod is the determination of the confidence intervals. Finally, we apply the above mentioned methods to data from the U.S. Tox21 research program and compare the results based on several tested substances and clearly demonstrate the...
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Dose-response curves
Hezoučký, Martin ; Hlávka, Zdeněk (advisor) ; Maciak, Matúš (referee)
Title: Dose-response curves Author: Martin Hezoučký Department: Department of Probability and Mathematical Statistics Supervisor: doc. RNDr. Zdeněk Hlávka, Ph.D., Department of Probability and Mathematical Statistics Abstract: In this thesis, we deal with the process of research and development of new medical substances with a focus on statistical methods used to determine appropriate doses. For this purpose, we examine the dose-response relationship. First, we describe a typical procedure for the development of a new drug. Second, we focus in detail on the MCP-Mod method. Third, we propose a new method based on the theory of gradual change models. This approach tests whether the administration of the drug has a significant effect. If so, the dose with desired effect is estimated using an appropriate model. Specifically, we provide an esti- mate using linear, quadratic and Emax gradual change models. We also describe a construction of a confidence interval for the point of change and also for the dose with the desired effect. The advantage of the proposed method over the MCP-Mod is the determination of the confidence intervals. Finally, we apply the above mentioned methods to data from the U.S. Tox21 research program and compare the results based on several tested substances and clearly demonstrate the...
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